CD30 Antibody [Ber-H2] (FITC)

• Background:

  The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen. CD30 can elicit signals leading to either activation or apoptosis through interaction with CD30 ligand (CD30L) . It is expressed by a subset of extrafollicular activated B and T cells, lung macrophages, activated NK cells, lymphomas, and endothelial cells. It is highly expressed on Hodgkins and Reed-Sternberg cells.

• NCBI Gene ID:

  943

• Swiss Prot:

  P28908

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  Ber-H2

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen.

• Symbol:

  TNFRSF8

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Schwarting, R., Gerdes, J., Durkop, H., Falini, B., Pileri, S., Stein, H. (1989) . BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope.Blood,74 (5), 1678-1689.

• Background Reference 02:

  Beljaards, R. C., Meijer, C. J., Scheffer, E., Toonstra, J., Van Vloten, W. A., Van Der Putte, S. C., ... Willemze, R. (1989) . Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients.The American journal of pathology,135 (6), 1169.

• Background Reference 03:

  Horie, R., Watanabe, T. (1998, December) . CD30: expression and function in health and disease. InSeminars in immunology (Vol. 10, No. 6, pp. 457-470) . Academic Press.

• Other Product Names:

  CD30, Ki-1, D1S166E, TNFRSF8

• Tested Applications:

  Flow

• Physical Properties:

  Liquid