CD30 Antibody [mCD30.1]

• Background:

  The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on activated T, B, NK, and monocyte cells. Its expression on activated T lymphocytes is regulated by cytokines and CD28. The ligand for CD30 is CD153. It has been suggested that the molecule plays a role in the protection against autoimmunity and the regulation of Th1 and Th2 cytokine secretion.

• NCBI Gene ID:

  21941

• Swiss Prot:

  Q60846

• Host:

  Hamster

• Reactivity:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  MCD30.1

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies, Functional Antibodies

• Field of Research:

  Apoptosis

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C . Do not freeze.

• Fragment:

  Armenian Hamster IgG

• Specificity:

  The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily.

• Symbol:

  Tnfrsf8

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 8

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Siegmund, T., Armitage, N., Wicker, L. S., Peterson, L. B., Todd, J. A., Lyons, P. A. (2000) . Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9. 2.Diabetes,49 (9), 1612-1616.

• Background Reference 02:

  Falini, B., Pileri, S., Pizzolo, G., D, H., Flenghi, L., Stirpe, F., ... Stein, H. (1995) . CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy.BLOOD-NEW YORK-,85, 1-1.

• Background Reference 03:

  Heath, W. R., Kurts, C., Caminschi, I., Carbone, F. R., Miller, J. F. (1999) . CD 30 prevents T‐cell responses to non‐lymphoid tissues.Immunological reviews,169 (1), 23-29.

• Other Product Names:

  Ki, Cd30, Ki-1, D1S166E, Tnfrsf8

• Tested Applications:

  Flow, Functional Assays

• Physical Properties:

  Liquid