IkB epsilon (Ab 22) Antibody

• Background:

  Inhibits NF-κ -B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-κ -B p50-p65 and p50-c-Rel complexes.

• NCBI Gene ID:

  4794

• Swiss Prot:

  O00221

• Accession Number:

  NP_004547.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  IkB-epsilon (Ab-22) antibody was raised against a peptide sequence around aa. 20~24 (I-E-S-L-R) derived from Human IkB-ε .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  40 kDa

• Specificity:

  This antibody detects endogenous level of total IkB-ε protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  NFKBIE

• NCBI Official Name:

  Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shirane M, et al. (1999) J Biol Chem; 274 (40) : 28169-74Karin, M. and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. ;18, 621-663. Chen, Z. J. et al. (1996) Cell; 84, 853-862. Brown, K. et al. (1995) Science; 267, 1485-1488.

• Other Product Names:

  IKBE, IKKA, TCF16, I-kappa-B-epsilon

• Tested Applications:

  WB, IHC

• Protein ID:

  71274109

• Physical Properties:

  Liquid