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IKK epsilon Antibody

CAT: 0223-2329-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-2329-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IKK epsilon Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. Iκ B is phosphorylated by Iκ B kinase (IKK) complex that contains IKKα , IKKβ , and IKKγ . A novel molecule in the IKK complex was recently identified and designated IKKε /IKK-i. IKK epsilon is required for the activation of NF-κ B by PMA and T cell receptors but not by TNFα and IL-1. IKKε /IKK-i message is expressed in a variety of tissues and is inducible by TNFα , IL-1, and LPS.
NCBI Gene ID
9641
Swiss Prot
Q14164
Accession Number
AF241789
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
2329
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Induced Expression Validation (Figure 1) : Raw 264.7 cells were treated with LPS (0.3 µg /mL) for different time period (3 hrs and 6 hrs) . IKK epsilon expression detected by anit-IKK epsilon antibodies (2329) was induced by LPS treatment and the expression levels were increased gradually at 3 hrs and 6 hrs. Induced Expression Validation2329
Field of Research
Signal Transduction
Purification
IKK epsilon Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Rat: (75%)
Buffer
IKK epsilon Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IKK epsilon antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
It has no cross response to IKKa, IKKb, or IKKy.
Isoform
Human IKK epsilon has 2 isoforms, including isoform 1 (716aa, 80kD) and isoform 2 (631aa, 70kD) . Mouse IKK epsilon has one isoform (717aa, 81kD) and Rat IKK epsilon also has one isoform (717aa, 80kD) . 2329 can detect human, mouse and possibly rat.
Symbol
IKBKE
Positive Control 2
Cat. No. 1307 - Human Pancreas Tissue Lysate
Positive Control 3
Cat. No. 11-101 - Human Pancreas Tissue Slide
Positive Control 4
Cat. No. 1202 - A431 Cell Lysate
Positive Control 5
Cat. No. 1224 - Daudi Cell Lysate
NCBI Official Name
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
NCBI Organism
Homo sapiens
Background Reference 01
Peters et al. Mol Cell 2000;5 (3) :513-22.
Background Reference 02
Shimada et al. Int Immunol 1999;11 (8) :1357-62 (WD0101) .
Other Product Names
IKK epsilon Antibody: IKKE, IKKI, IKK-E, IKK-i, IKKE, KIAA0151, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Inducible I kappa-B kinase, I-kappa-B kinase epsilon
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7288877
Physical Properties
Liquid

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