SAPK / JNK (Ab 183) Antibody

• Background:

  Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.

• NCBI Gene ID:

  5601

• Swiss Prot:

  P45984; ; ; P53779

• Accession Number:

  NP_001128516.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  SAPK/JNK (Ab-183) antibody was raised against a peptide sequence around aa.181~185 (M-M-T-P-Y) derived from Human SAPK/JNK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  46, 54 kDa

• Specificity:

  This antibody detects endogenous level of total SAPK/JNK protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  MAPK9

• NCBI Official Name:

  Mitogen-activated protein kinase 9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ferrer, et al. (2003) Neuropathology & Applied Neurobiology 29: 23 Zhonghong Guan, et al. (1999) J Biol Chem, Vol. 274: 36200-36206D. Margriet Ouwens1, et al. (2002) The EMBO Journal 21: 3782–3793, S Matsuyoshi1, et al. (2006) British Journal of Cancer 94: 532

• Other Product Names:

  JNK2, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, SAPK1a, JNK2BETA, p54aSAPK, JNK2ALPHA, CDHN, NCAD, JNK2

• Tested Applications:

  WB, IHC

• Protein ID:

  205277412

• Physical Properties:

  Liquid