IGF 1R (Ab 1161) Antibody

• Background:

  This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

• NCBI Gene ID:

  3480

• Swiss Prot:

  P08069

• Accession Number:

  NP_000866.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  IGF-1R (Ab-1161) antibody was raised against a peptide sequence around aa.1159~1163 (D-I-Y-E-T) derived from Human IGF-1R .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  200 95 kDa

• Specificity:

  This antibody detects endogenous level of total IGF-1R protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

• Symbol:

  IGF1R

• NCBI Official Name:

  Insulin-like growth factor 1 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Li S, et al. (1994) J Biol Chem; 269 (51) . Hernandez-Sanchez C, et al. (1995) J Biol Chem.

• Other Product Names:

  IGFR, CD221, IGFIR, JTK13, MACS, PRKCSL, Insulin-like growth factor I receptor, IGF1R, kinase IGF1R

• Tested Applications:

  WB, IHC, IF

• Protein ID:

  4557665

• Physical Properties:

  Liquid