Trim5a Antibody [3B11H2]

• Background:

  TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5α , which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

• NCBI Gene ID:

  85364

• Swiss Prot:

  Q9NUD5

• Accession Number:

  Q9NUD5

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  3B11H2

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Trim5α monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  ZCCHC3

• NCBI Official Name:

  Zinc finger, CCHC domain containing 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stremlau, M. Nature 2004.427:848-53.

• Background Reference 02:

  Song, B. J Virol. 2005.79 (7) :3930-7.

• Other Product Names:

  C20orf99C20orf99

• Tested Applications:

  WB, IHC

• Protein ID:

  23396534