S100B Antibody [9A11B9]

• Background:

  S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S100B are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin B is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

• NCBI Gene ID:

  6285

• Swiss Prot:

  P04271

• Accession Number:

  P04271

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified full-length recombinant S100B-GST expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  9A11B9

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Concentration:

  Batch dependent

• Buffer:

  Ascitic fluid containing 0.03% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  S100B monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  S100B

• NCBI Official Name:

  S100 calcium binding protein B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shapiro LA. Marks A. Whitaker-Azmitia PM. Brain Res. 2004, Jun 4,1010 (1-2) :17-21.

• Background Reference 02:

  Sorci G. Riuzzi F. Arcuri C. et al. Mol Cell Biol. 2004, Jun,24 (11) :4880-94.

• Background Reference 03:

  Zimmer DB. Chaplin J. Baldwin A. et al. Cell Mol Biol (Noisy-le-grand) .2005, Sep 5,51 (2) :201-14.

• Other Product Names:

  S-100 protein beta chainNEF, S100, S100-B, S100beta

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  134138