S100B/S-100 Antibody

• Background:

  The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

• NCBI Gene ID:

  6285

• Swiss Prot:

  P04271

• Accession Number:

  P04271

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the Central region of human S100B/S-100.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  11 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  S100B

• NCBI Official Name:

  Protein S100-B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sahoo, N., et al. FEBS Lett. 584 (18) :3896-3900 (2010)

• Background Reference 02:

  Lin, J., et al. J. Biol. Chem. 285 (35) :27487-27498 (2010)

• Background Reference 03:

  Van Dieck, J., et al. FEBS Lett. 584 (15) :3269-3274 (2010)

• Background Reference 04:

  Egberts, F., et al. Anticancer Res. 30 (5) :1799-1805 (2010)

• Other Product Names:

  Protein S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B, S100B

• Tested Applications:

  WB

• Protein ID:

  134138

• Physical Properties:

  Liquid