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GLP Antibody [1B7B4]

CAT: 0223-32-161Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-32-161Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.
NCBI Gene ID
79813
Swiss Prot
Q9H9B1
Accession Number
Q9H9B1
Host
Mouse
Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3) .
Clonality
Monoclonal
Clone
1B7B4
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Antibody is purified by protein A affinity chromatography.
Concentration
Batch dependent
Buffer
Purified antibody in PBS containing 0.03% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GLP monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG1
Symbol
EHMT1
NCBI Official Name
Euchromatic histone-lysine N-methyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27.
Background Reference 02
Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38 (5-6) :845-859.
Background Reference 03
Andrew Young Adv Pharmacol. 2005;52:151-71.
Other Product Names
EUHMTASE1, GLP, KIAA1876, KMT1D, Euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, GLP1, FP13812, EUHMTASE1, bA188C12.1, RP11-188C12.1
Tested Applications
ELISA, WB
Protein ID
325511404

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