CFP Antibody

• Background:

  This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections.

• NCBI Gene ID:

  5199

• Swiss Prot:

  P27918

• Accession Number:

  P27918

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-223 amino acids from the Central region of human CFP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CFP

• NCBI Official Name:

  Properdin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Seitsonen, S., et al. Mol. Immunol. 47 (6) :1334-1336 (2010)

• Background Reference 02:

  Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)

• Background Reference 03:

  Wolf-Schnurrbusch, U.E., et al. Retina (Philadelphia, Pa.) 29 (7) :966-973 (2009)

• Background Reference 04:

  Keslar, K., et al. Transplantation 86 (9) :1319-1321 (2008)

• Other Product Names:

  Properdin, Complement factor P, CFP, PFC

• Tested Applications:

  WB, Flow

• Protein ID:

  464473

• Physical Properties:

  Liquid