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RGR Antibody

CAT: 0223-64-174Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-174Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively) .
NCBI Gene ID
5995
Swiss Prot
P47804
Accession Number
P47804
Host
Rabbit
Reactivity
Human
Immunogen
This RGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-291 amino acids from the Central region of human RGR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Symbol
RGR
NCBI Official Name
RPE-retinal G protein-coupled receptor
NCBI Organism
Homo sapiens
Background Reference 01
Kochounian, H., et al. Exp. Eye Res. 88 (6) :1129-1136 (2009)
Background Reference 02
Radu, R.A., et al. J. Biol. Chem. 283 (28) :19730-19738 (2008)
Background Reference 03
Luttrell, L.M. Mol. Biotechnol. 39 (3) :239-264 (2008)
Background Reference 04
Lin, M.Y., et al. Mol. Vis. 13, 1203-1214 (2007)
Other Product Names
RPE-retinal G protein-coupled receptor, RGR
Tested Applications
WB, IHC-P, Flow
Protein ID
1350592
Physical Properties
Liquid

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