CAPN3 Antibody

• Background :

  Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A.

• NCBI Gene ID :

  825

• Swiss Prot :

  P20807

• Accession Number :

  P20807

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CAPN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-632 amino acids from the C-terminal region of human CAPN3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  94 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CAPN3

• NCBI Official Name :

  Calpain-3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Charlton, R., et al. Neuromuscul. Disord. 19 (7) :449-457 (2009)

• Background Reference 02 :

  Moretti, D., et al. Carcinogenesis 30 (6) :960-967 (2009)

• Background Reference 03 :

  Enjuanes, A., et al. Cancer Res. 68 (24) :10178-10186 (2008)

• Background Reference 04 :

  Beckmann, J.S., et al. Neuromuscul. Disord. 18 (12) :913-921 (2008)

• Other Product Names :

  Calpain-3, Calcium-activated neutral proteinase 3, CANP 3, Calpain L3, Calpain p94, Muscle-specific calcium-activated neutral protease 3, New calpain 1, nCL-1, CAPN3, CANP3, CANPL3, NCL1

• Tested Applications :

  WB, IHC-P, Flow

• Physical Properties :

  Liquid