GRPR Antibody

• Background:

  Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

• NCBI Gene ID:

  2925

• Swiss Prot:

  P30550

• Accession Number:

  P30550

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GRPR

• NCBI Official Name:

  Gastrin-releasing peptide receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)

• Background Reference 02:

  Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)

• Background Reference 03:

  Chao, C., et al. J. Surg. Res. 156 (1) :26-31 (2009)

• Background Reference 04:

  Ananias, H.J., et al. Prostate 69 (10) :1101-1108 (2009)

• Other Product Names:

  Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  232185

• Physical Properties:

  Liquid