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GRPR Antibody

CAT: 0223-64-118Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-118Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
NCBI Gene ID
2925
Swiss Prot
P30550
Accession Number
P30550
Host
Rabbit
Reactivity
Human
Immunogen
This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
GRPR
NCBI Official Name
Gastrin-releasing peptide receptor
NCBI Organism
Homo sapiens
Background Reference 01
Guey, L.T., et al. Eur. Urol. 57 (2) :283-292 (2010)
Background Reference 02
Chapuis, J., et al. Mol. Psychiatry 14 (11) :1004-1016 (2009)
Background Reference 03
Chao, C., et al. J. Surg. Res. 156 (1) :26-31 (2009)
Background Reference 04
Ananias, H.J., et al. Prostate 69 (10) :1101-1108 (2009)
Other Product Names
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
Tested Applications
WB, IHC-P, Flow
Protein ID
232185
Physical Properties
Liquid

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