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GPI Antibody

CAT: 0223-64-115Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-115Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
NCBI Gene ID
2821
Swiss Prot
P06744
Accession Number
P06744
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-473 amino acids from the C-terminal region of human GPI.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
63 kDa
Fragment
Rabbit Ig
Symbol
GPI
NCBI Official Name
Glucose-6-phosphate isomerase
NCBI Organism
Homo sapiens
Background Reference 01
Shih, W.L., et al. Cancer Lett. 290 (2) :223-237 (2010)
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
Araki, K., et al. J. Biol. Chem. 284 (47) :32305-32311 (2009)
Background Reference 04
Tsutsumi, S., et al. Int. J. Oncol. 35 (5) :1117-1121 (2009)
Other Product Names
Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Sperm antigen 36, SA-36, GPI
Tested Applications
WB, Flow
Protein ID
17380385
Physical Properties
Liquid

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