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ATP6V1A Antibody

CAT: 0223-64-110Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-110Size:400 µL
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Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.
NCBI Gene ID
523
Swiss Prot
P38606
Accession Number
P38606
Host
Rabbit
Reactivity
Human
Immunogen
This ATP6V1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-468 amino acids from the Central region of human ATP6V1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
ATP6V1A
NCBI Official Name
V-type proton ATPase catalytic subunit A
NCBI Organism
Homo sapiens
Background Reference 01
Martins-de-Souza, D., et al.Psychiatr Res 43 (11) :978-986 (2009)
Background Reference 02
Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009)
Background Reference 03
Lu, M., et al. J. Biol. Chem. 282 (34) :24495-24503 (2007)
Background Reference 04
Ahmed, M., et al. J. Proteome Res. 4 (3) :931-940 (2005)
Other Product Names
V-type proton ATPase catalytic subunit A, V-ATPase subunit A, V-ATPase 69 kDa subunit, Vacuolar ATPase isoform VA68, Vacuolar proton pump subunit alpha, ATP6V1A, ATP6A1, ATP6V1A1, VPP2
Tested Applications
WB, IHC-P
Protein ID
22096378
Physical Properties
Liquid

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