ATP5A1 Antibody

• Background:

  This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c) . This gene encodes the alpha subunit of the catalytic core.

• NCBI Gene ID:

  498

• Swiss Prot:

  P25705

• Accession Number:

  P25705

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ATP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-503 amino acids from the C-terminal region of human ATP5A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ATP5A1

• NCBI Official Name:

  ATP synthase subunit alpha, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pandey, N.R., et al. Am. J. Pathol. 175 (4) :1777-1787 (2009)

• Background Reference 02:

  Seth, R., et al. J. Clin. Pathol. 62 (7) :598-603 (2009)

• Background Reference 03:

  Law, I.K., et al. Proteomics 9 (9) :2444-2456 (2009)

• Background Reference 04:

  Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009)

• Other Product Names:

  ATP synthase subunit alpha, mitochondrial, ATP5A1, ATP5A, ATP5AL2, ATPM

• Tested Applications:

  WB, IHC-P

• Protein ID:

  114517

• Physical Properties:

  Liquid