PRUNE Antibody

• Background:

  Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. It plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

• NCBI Gene ID:

  58497

• Swiss Prot:

  Q86TP1

• Accession Number:

  Q86TP1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PRUNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-389 amino acids from the C-terminal region of human PRUNE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PRUNE

• NCBI Official Name:

  Protein prune homolog

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vieira, A.R., et al. Genet. Med. 10 (9) :668-674 (2008)

• Background Reference 02:

  Middelhaufe, S., et al. Biochem. J. 407 (2) :199-205 (2007)

• Background Reference 03:

  Kobayashi, T., et al. Mol. Cell. Biol. 26 (3) :898-911 (2006)

• Background Reference 04:

  Zollo, M., et al. Clin. Cancer Res. 11 (1) :199-205 (2005)

• Other Product Names:

  Protein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  229462737

• Physical Properties:

  Liquid