INSC Antibody

• Background :

  In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]) .

• NCBI Gene ID :

  387755

• Swiss Prot :

  Q1MX18

• Accession Number :

  Q1MX18

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This INSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the Central region of human INSC.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  63 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  INSC

• NCBI Official Name :

  Protein inscuteable homolog

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Vural, A., et al. Mol. Cell. Biol. 30 (6) :1528-1540 (2010)

• Background Reference 02 :

  Rivadeneira, F., et al. Nat. Genet. 41 (11) :1199-1206 (2009)

• Background Reference 03 :

  Izaki, T., et al. Biochem. Biophys. Res. Commun. 341 (4) :1001-1006 (2006)

• Background Reference 04 :

  Katoh, M., et al. Int. J. Mol. Med. 11 (1) :111-116 (2003)

• Other Product Names :

  Protein inscuteable homolog, INSC

• Tested Applications :

  WB, IHC-P

• Protein ID :

  116248172

• Physical Properties :

  Liquid