KCE1L Antibody

• Background:

  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. This intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome.

• NCBI Gene ID:

  23630

• Swiss Prot:

  Q9UJ90

• Accession Number:

  Q9UJ90

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KCE1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the Central region of human KCE1L.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  15 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KCNE1L

• NCBI Official Name:

  Potassium voltage-gated channel subfamily E member 1-like protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ravn, L.S., et al. Heart Rhythm 5 (3) :427-435 (2008)

• Background Reference 02:

  Lundquist, A.L., et al. Genomics 87 (1) :119-128 (2006)

• Background Reference 03:

  Ravn, L.S., et al. Am. J. Cardiol. 96 (3) :405-407 (2005)

• Background Reference 04:

  Yang, Y., et al. Am. J. Hum. Genet. 75 (5) :899-905 (2004)

• Other Product Names:

  Potassium voltage-gated channel subfamily E member 1-like protein, AMME syndrome candidate gene 2 protein, KCNE1L, AMMECR2

• Tested Applications:

  WB

• Physical Properties:

  Liquid