ABCD2 Antibody

• Background:

  ABCD2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters.

• NCBI Gene ID:

  225

• Swiss Prot:

  Q9UBJ2

• Accession Number:

  Q9UBJ2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-298 amino acids from the Central region of human ABCD2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  83 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ABCD2

• NCBI Official Name:

  ATP-binding cassette sub-family D member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Saito, A., et al. J. Hum. Genet. 54 (6) :317-323 (2009)

• Background Reference 02:

  Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377 (1) :176-180 (2008)

• Background Reference 03:

  Lu, Y., et al. J. Lipid Res. 49 (12) :2582-2589 (2008)

• Other Product Names:

  ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP

• Tested Applications:

  WB

• Protein ID:

  12643305

• Physical Properties:

  Liquid