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ABCD1 Antibody

CAT: 0223-55-187Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-187Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
NCBI Gene ID
215
Swiss Prot
P33897
Accession Number
P33897
Host
Rabbit
Reactivity
Human
Immunogen
This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Symbol
ABCD1
NCBI Official Name
ATP-binding cassette sub-family D member 1
NCBI Organism
Homo sapiens
Background Reference 01
Matsukawa, T., et al. Neurogenetics (2010) In press :
Background Reference 02
Xie, H.H., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (2) :144-148 (2010)
Background Reference 03
Li, J.Y., et al. J. Neurol. Sci. 290 (1-2), 163-165 (2010) :
Background Reference 04
Hour, T.C., et al. Int. J. Biol. Markers 24 (3) :171-178 (2009)
Other Product Names
ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP, ABCD1, ALD
Tested Applications
WB, IHC-P, Flow
Protein ID
67476960
Physical Properties
Liquid

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