ABCD1 Antibody

• Background:

  ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.

• NCBI Gene ID:

  215

• Swiss Prot:

  P33897

• Accession Number:

  P33897

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  83 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ABCD1

• NCBI Official Name:

  ATP-binding cassette sub-family D member 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Matsukawa, T., et al. Neurogenetics (2010) In press :

• Background Reference 02:

  Xie, H.H., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 (2) :144-148 (2010)

• Background Reference 03:

  Li, J.Y., et al. J. Neurol. Sci. 290 (1-2), 163-165 (2010) :

• Background Reference 04:

  Hour, T.C., et al. Int. J. Biol. Markers 24 (3) :171-178 (2009)

• Other Product Names:

  ATP-binding cassette sub-family D member 1, Adrenoleukodystrophy protein, ALDP, ABCD1, ALD

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  67476960

• Physical Properties:

  Liquid