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AANAT Antibody

CAT: 0223-64-035Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-035Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
NCBI Gene ID
15
Swiss Prot
Q16613
Accession Number
Q16613
Host
Rabbit
Reactivity
Human
Immunogen
This AANAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-54 amino acids from the N-terminal region of human AANAT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AANAT
NCBI Official Name
Serotonin N-acetyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Mansour, H.A., et al. Bipolar Disord 11 (7) :701-710 (2009)
Background Reference 02
Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009)
Background Reference 03
Anderson, B.M., et al. Neurogenetics 10 (3) :209-216 (2009)
Other Product Names
Serotonin N-acetyltransferase, Serotonin acetylase, Aralkylamine N-acetyltransferase, AA-NAT, AANAT, SNAT
Tested Applications
WB
Protein ID
11387096
Physical Properties
Liquid

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