GEN1 Antibody

• Background:

  Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded (By similarity) .

• NCBI Gene ID:

  348654

• Swiss Prot:

  Q17RS7

• Accession Number:

  Q17RS7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human GEN1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  103 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GEN1

• NCBI Official Name:

  Flap endonuclease GEN homolog 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ip, S.C., et al. Nature 456 (7220) :357-361 (2008)

• Background Reference 02:

  Ishikawa, G., et al. Nucleic Acids Res. 32 (21) :6251-6259 (2004)

• Other Product Names:

  Flap endonuclease GEN homolog 1, 31--, GEN1

• Tested Applications:

  WB

• Protein ID:

  290457644

• Physical Properties:

  Liquid