DBC1 Antibody

• Background:

  DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

• NCBI Gene ID:

  1620

• Swiss Prot:

  O60477

• Accession Number:

  O60477

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DBC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the N-terminal region of human DBC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  89 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  BRINP1

• NCBI Official Name:

  BMP/retinoic acid-inducible neural-specific protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Koyama, S., et al. Biochem. Biophys. Res. Commun. 392 (3) :357-362 (2010)

• Background Reference 02:

  Gronbaek, K., et al. Mod. Pathol. 21 (5) :632-638 (2008)

• Background Reference 03:

  Louhelainen, J.P., et al. Oncogene 25 (16) :2409-2419 (2006)

• Background Reference 04:

  Izumi, H., et al. Hum. Mol. Genet. 14 (8) :997-1007 (2005)

• Other Product Names:

  BMP/retinoic acid-inducible neural-specific protein 1, Deleted in bladder cancer protein 1, BRINP1, DBC1, DBCCR1, FAM5A

• Tested Applications:

  WB

• Physical Properties:

  Liquid