HAMP Antibody

• Background:

  HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.

• NCBI Gene ID:

  57817

• Swiss Prot:

  P81172

• Accession Number:

  P81172

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  9 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:500

• Symbol:

  HAMP

• NCBI Official Name:

  Hepcidin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Matsumoto, M., et al. Circ. J. 74 (2) :301-306 (2010)

• Background Reference 02:

  Del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94 (12) :5102-5107 (2009)

• Background Reference 03:

  Kwapisz, J., et al.Zhejiang Univ Sci10 (11) :791-795 (2009)

• Background Reference 04:

  Barton, J.C., et al. Am. J. Hematol. 84 (11) :710-714 (2009)

• Other Product Names:

  Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1

• Tested Applications:

  WB

• Protein ID:

  10720397

• Physical Properties:

  Liquid