HAMP Antibody

CAT: 0223-63-955Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-955Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
NCBI Gene ID
57817
Swiss Prot
P81172
Accession Number
P81172
Host
Rabbit
Reactivity
Human
Immunogen
This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
9 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500
Symbol
HAMP
NCBI Official Name
Hepcidin
NCBI Organism
Homo sapiens
Background Reference 01
Matsumoto, M., et al. Circ. J. 74 (2) :301-306 (2010)
Background Reference 02
Del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94 (12) :5102-5107 (2009)
Background Reference 03
Kwapisz, J., et al.Zhejiang Univ Sci10 (11) :791-795 (2009)
Background Reference 04
Barton, J.C., et al. Am. J. Hematol. 84 (11) :710-714 (2009)
Other Product Names
Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1
Tested Applications
WB
Protein ID
10720397
Physical Properties
Liquid

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