HBA2 Antibody

• Background:

  HBA2 located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.

• NCBI Gene ID:

  30393040

• Swiss Prot:

  P69905

• Accession Number:

  P69905

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This HBA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the Central region of human HBA2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  15 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HBA1

• NCBI Official Name:

  Hemoglobin subunit alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sessa, R., et al. Am. J. Hematol. 85 (2) :143-144 (2010)

• Background Reference 02:

  Sharma, V., et al. Hematology 14 (5) :297-300 (2009)

• Background Reference 03:

  Waye, J.S., et al. Hemoglobin 33 (6) :519-522 (2009)

• Background Reference 04:

  Roy, P., et al. Hemoglobin 33 (6) :486-491 (2009)

• Other Product Names:

  Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain, HBA1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  57013850

• Physical Properties:

  Liquid