CHIA Antibody

CAT: 0223-63-924Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-924Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2) -specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
NCBI Gene ID
27159
Swiss Prot
Q9BZP6
Accession Number
Q9BZP6
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CHIA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CHIA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Symbol
CHIA
NCBI Official Name
Acidic mammalian chitinase
NCBI Organism
Homo sapiens
Background Reference 01
Wu, A.C., et al. J. Allergy Clin. Immunol. 125 (3) :754-757 (2010)
Background Reference 02
Ober, C., et al. Curr Opin Allergy Clin Immunol 9 (5) :401-408 (2009)
Background Reference 03
Seibold, M.A., et al. J. Biol. Chem. 284 (29) :19650-19658 (2009)
Background Reference 04
Hartl, D., et al. J. Immunol. 182 (8) :5098-5106 (2009)
Other Product Names
Acidic mammalian chitinase, AMCase, Lung-specific protein TSA1902, CHIA
Tested Applications
WB, Flow
Protein ID
37999771
Physical Properties
Liquid

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