CHIA Antibody

• Background :

  CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2) -specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.

• NCBI Gene ID :

  27159

• Swiss Prot :

  Q9BZP6

• Accession Number :

  Q9BZP6

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This CHIA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-47 amino acids from the N-terminal region of human CHIA.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  52 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CHIA

• NCBI Official Name :

  Acidic mammalian chitinase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Wu, A.C., et al. J. Allergy Clin. Immunol. 125 (3) :754-757 (2010)

• Background Reference 02 :

  Ober, C., et al. Curr Opin Allergy Clin Immunol 9 (5) :401-408 (2009)

• Background Reference 03 :

  Seibold, M.A., et al. J. Biol. Chem. 284 (29) :19650-19658 (2009)

• Background Reference 04 :

  Hartl, D., et al. J. Immunol. 182 (8) :5098-5106 (2009)

• Other Product Names :

  Acidic mammalian chitinase, AMCase, Lung-specific protein TSA1902, CHIA

• Tested Applications :

  WB, Flow

• Protein ID :

  37999771

• Physical Properties :

  Liquid