CROT Antibody

• Background:

  CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.

• NCBI Gene ID:

  54677

• Swiss Prot:

  Q9UKG9

• Accession Number:

  Q9UKG9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CROT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human CROT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  70 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CROT

• NCBI Official Name:

  Peroxisomal carnitine O-octanoyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Li, Y.L., et al. FEBS J. 276 (1) :303-314 (2009)

• Background Reference 02:

  Morillas, M., et al. J. Biol. Chem. 277 (13) :11473-11480 (2002)

• Background Reference 03:

  Van der Leij, F.R., et al. Mol. Genet. Metab. 71 (1-2), 139-153 (2000) :

• Background Reference 04:

  Ferdinandusse, S., et al. Biochem. Biophys. Res. Commun. 263 (1) :213-218 (1999)

• Other Product Names:

  Peroxisomal carnitine O-octanoyltransferase, COT, CROT, COT

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  48429265

• Physical Properties:

  Liquid