PLCB1 Antibody

• Background:

  The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.

• NCBI Gene ID:

  23236

• Swiss Prot:

  Q9NQ66

• Accession Number:

  Q9NQ66

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PLCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the C-terminal region of human PLCB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  139 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PLCB1

• NCBI Official Name:

  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

• Background Reference 02:

  Woodcock, E.A., et al. J. Mol. Cell. Cardiol. 47 (5) :676-683 (2009)

• Background Reference 03:

  Zhang, Y., et al. J. Recept. Signal Transduct. Res. 29 (1) :52-62 (2009)

• Other Product Names:

  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, PLC-154, Phosphoinositide phospholipase C-beta-1, Phospholipase C-I, PLC-I, Phospholipase C-beta-1, PLC-beta-1, PLCB1, KIAA0581

• Tested Applications:

  WB, Flow

• Protein ID:

  12643814

• Physical Properties:

  Liquid