GUSB Antibody

• Background:

  The GUSB gene encodes beta-glucuronidase (EC 3.2.1.31), a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans (Shipley et al., 1993 [PubMed 7680524]) . It is a tetrameric glycoprotein composed of identical subunits (Oshima et al., 1987 [PubMed 3468507]) . The GUSB gene is mutated in mucopolysaccharidosis type VII (MPS7; MIM 253220) .

• NCBI Gene ID:

  2990

• Swiss Prot:

  P08236

• Accession Number:

  P08236

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GUSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-362 amino acids from the Central region of human GUSB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  75 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GUSB

• NCBI Official Name:

  Beta-glucuronidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tomatsu, S. Hum. Mutat. 30 (4), 511-519 (2009)

• Background Reference 02:

  Romanowski, T. Med. Sci. Monit. 14 (7), BR147-BR152 (2008)

• Background Reference 03:

  Gratz, M. Pharmacogenet. Genomics 15 (12), 875-881 (2005)

• Other Product Names:

  Beta-glucuronidase, Beta-G1, GUSB

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  146345377

• Physical Properties:

  Liquid