XDH Antibody

• Background:

  XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

• NCBI Gene ID:

  7498

• Swiss Prot:

  P47989

• Accession Number:

  P47989

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This XDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the N-terminal region of human XDH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  146 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  XDH

• NCBI Official Name:

  Xanthine dehydrogenase/oxidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ross, C.J., et.al., Nat. Genet. 41 (12), 1345-1349 (2009)

• Background Reference 02:

  Taibi, G., et.al., J. Cell. Biochem. 108 (3), 688-692 (2009)

• Background Reference 03:

  Spiekermann, S., et.al., Eur. Respir. J. 34 (1), 276 (2009)

• Other Product Names:

  Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase, XD, Xanthine oxidase, XO, Xanthine oxidoreductase, XOR, XDH, XDHA

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  2506326

• Physical Properties:

  Liquid