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CIRBP Antibody

CAT: 0223-63-800Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-800Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.
NCBI Gene ID
1153
Swiss Prot
Q14011
Accession Number
Q14011
Host
Rabbit
Reactivity
Human
Immunogen
This CIRBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Hamster
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Symbol
CIRBP
NCBI Official Name
Cold-inducible RNA-binding protein
NCBI Organism
Homo sapiens
Background Reference 01
Colinge J., et.al., Submitted (OCT-2008) to UniProtKB.
Background Reference 02
Yang R., et.al., Nucleic Acids Res. 34:1224-1236 (2006) .
Other Product Names
Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP
Tested Applications
WB, IHC-P
Protein ID
5921786
Physical Properties
Liquid

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