ACR Antibody

• Background:

  ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.

• NCBI Gene ID:

  49

• Swiss Prot:

  P10323

• Accession Number:

  P10323

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ACR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-416 amino acids from the C-terminal region of human ACR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ACR

• NCBI Official Name:

  Acrosin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dube, C., et.al., J. Androl. 26 (4), 519-528 (2005)

• Background Reference 02:

  Furlong, L.I., et.al., Fertil. Steril. 83 (6), 1791-1796 (2005)

• Other Product Names:

  Acrosin, Acrosin light chain, Acrosin heavy chain, ACR, ACRS

• Tested Applications:

  WB, IHC-P

• Protein ID:

  115502349

• Physical Properties:

  Liquid