SPG20 Antibody

• Background:

  SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor.

• NCBI Gene ID:

  23111

• Swiss Prot:

  Q8N0X7

• Accession Number:

  Q8N0X7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SPG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human SPG20.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  73 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SPG20

• NCBI Official Name:

  Spartin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Milewska, M., et.al., J. Neurochem. 111 (4), 1022-1030 (2009)

• Background Reference 02:

  Edwards, T.L., et.al., Biochem. J. 423 (1), 31-39 (2009) .

• Other Product Names:

  Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  50401600

• Physical Properties:

  Liquid