TP73 Antibody

• Background :

  TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.

• NCBI Gene ID :

  7161

• Swiss Prot :

  O15350

• Accession Number :

  O15350

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This TP73 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the Central region of human TP73.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  70 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  TP73

• NCBI Official Name :

  Tumor protein p73

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Mai, M., et.al., Genomics 51 (3), 359-363 (1998) Mai, M., et.al., Oncogene 17 (13), 1739-1741 (1998)

• Other Product Names :

  Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73

• Tested Applications :

  WB, IHC-P, IF, Flow

• Physical Properties :

  Liquid