COQ3 Antibody

CAT: 0223-63-632Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-632Size:400 µL
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Background
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]) . This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. COQ3 is an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.
NCBI Gene ID
51805
Swiss Prot
Q9NZJ6
Accession Number
Q9NZJ6
Host
Rabbit
Reactivity
Human
Immunogen
This COQ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human COQ3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Symbol
COQ3
NCBI Official Name
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Olsen, J.V., et.al., Cell 127 (3), 635-648 (2006)
Other Product Names
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial, 2-polyprenyl-6-hydroxyphenol methylase,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, DHHB methyltransferase, DHHB-MT, DHHB-MTase, 3-demethylubiquinone-10 3-methyltransferase, Dihydroxyhexaprenylbenzoate methyltransferase, COQ3
Tested Applications
WB, IHC-P, Flow
Protein ID
313104241
Physical Properties
Liquid

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