SLC11A1 Antibody

• Background:

  NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

• NCBI Gene ID:

  6556

• Swiss Prot:

  P49279

• Accession Number:

  P49279

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SLC11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-276 amino acids from the Central region of human SLC11A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SLC11A1

• NCBI Official Name:

  Natural resistance-associated macrophage protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jin, J., et.al., Zhongguo Dang Dai Er Ke Za Zhi 11 (4), 283-287 (2009)

• Background Reference 02:

  Liu, J., et.al., Am. J. Hum. Genet. 56 (4), 845-853 (1995)

• Other Product Names:

  Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1, SLC11A1, LSH, NRAMP, NRAMP1

• Tested Applications:

  WB, IF

• Protein ID:

  1352521

• Physical Properties:

  Liquid