SLC12A1 Antibody

CAT: 0223-14-736Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-14-736Size:100 µL
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Background
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
NCBI Gene ID
6557
Swiss Prot
Q13621
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SLC12A1 (NP_000329.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
Mouse kidney
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 150kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
SLC12A1
Positive Control 2
Rat kidney
NCBI Official Name
Solute carrier family 12 (sodium/potassium/chloride transporter), member 1
NCBI Organism
Homo sapiens
Other Product Names
SLC12A1, BSC1, MGC48843, NKCC2
Tested Applications
WB
Physical Properties
Liquid

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