Calcineurin Antibody

• Background:

  PPP3CA is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. PPP3CA dephosphorylates HSPB1 and SSH1.

• NCBI Gene ID:

  5530

• Swiss Prot:

  Q08209

• Accession Number:

  Q08209

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Calcineurin (PPP3CA) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-51 amino acids from the N-terminal region of human Calcineurin (PPP3CA) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PPP3CA

• NCBI Official Name:

  Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rodriguez, A., et al., J. Biol. Chem. 280 (11) :9980-9984 (2005) . Shirane, M., et al., Nat. Cell Biol. 5 (1) :28-37 (2003) . Bengoechea-Alonso, M.T., et al., Nitric Oxide 8 (1) :65-74 (2003) . Huai, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (19) :12037-12042 (2002) . Bennasser, Y., et al., Virology 303 (1) :174-180 (2002) .

• Other Product Names:

  Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, PPP3CA, CALNA, CNA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1352673

• Physical Properties:

  Liquid