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R MKP3 Antibody

CAT: 0223-63-473Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-473Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK) . MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis
NCBI Gene ID
116663
Swiss Prot
Q64346
Accession Number
Q64346
Host
Rabbit
Reactivity
Rat
Immunogen
This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by dialysis against PBS
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Symbol
Dusp6
NCBI Official Name
Dual specificity protein phosphatase 6
NCBI Organism
Rattus norvegicus
Background Reference 01
Muda, M., et al. J. Biol. Chem. 271 (8), 4319-4326 (1996)
Background Reference 02
Mourey, R.J., et al. J. Biol. Chem. 271 (7), 3795-3802 (1996)
Other Product Names
Dual specificity protein phosphatase 6, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, Dusp6, Mkp3
Tested Applications
WB, Flow
Physical Properties
Liquid

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