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LDL-R Antibody

CAT: 0223-5163-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5163-01Size:0.02 mg
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Background
LDL-R Antibody: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
NCBI Gene ID
3949
Swiss Prot
P01130
Accession Number
NP_000518
Host
Chicken
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
LDL-R Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (89%), Rabbit: (80%)
Buffer
LDL-R Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LDL-R antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgY
Symbol
LDLR
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Low density lipoprotein receptor
NCBI Organism
Homo sapiens
Background Reference 01
Li Y, Cam J, and Bu G. Low-density lipoprotein receptor family: endocytosis and signal transduction. Mol. Neurobiol.2001; 23:53-67.
Background Reference 02
Austin MA, Hutter CM, Zimmern RL, et al. Familial hypercholesterolemia and coronary heart disease: a HuGE association review. Am. J. Epidemiol.2004; 160:421-9.
Background Reference 03
Helle F and Dubuisson J. Hepatitis C virus entry into host cells. Cell Mol. Life Sci.2008; 65:100-12.
Other Product Names
LDL-R Antibody: FH, FHC, LDLCQ2, Low-density lipoprotein receptor, LDL receptor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4504975
Physical Properties
Liquid

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