PRL1 Antibody

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.

7803

Q93096

Q93096

Human, Mouse

This PRL1 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1.

Unconjugated

Primary Antibodies

Signal Transduction

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

20 kDa

Rabbit Ig

For WB starting dilution is: 1:1000

PTP4A1

Protein tyrosine phosphatase type IVA 1

Homo sapiens

Jeong, D.G., et al. J. Mol. Biol. 345 (2), 401-413 (2005)

Werner, S.R., et al. Cancer Lett. 202 (2), 201-211 (2003)

Wang, J., et al. J. Biol. Chem. 277 (48), 46659-46668 (2002)

Nicolas, G., et al. Mol. Cell. Biol. 22 (10), 3527-3536 (2002)

Protein tyrosine phosphatase type IVA 1, PTP (CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1

WB

68566217