PRL3 Antibody

CAT: 0223-63-469Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-469Size:400 µL
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Background
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) . PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
NCBI Gene ID
11156
Swiss Prot
O75365
Accession Number
O75365
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PRL3 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTP4A3
NCBI Official Name
Protein tyrosine phosphatase type IVA 3
NCBI Organism
Homo sapiens
Background Reference 01
Kato, H., et al. Clin. Cancer Res. 10 (21), 7318-7328 (2004)
Background Reference 02
Wu, X., et al. Am. J. Pathol. 164 (6), 2039-2054 (2004)
Background Reference 03
Kim, K.A., et al. FEBS Lett. 565 (1-3), 181-187 (2004)
Background Reference 04
Kozlov, G., et al. J. Biol. Chem. 279 (12), 11882-11889 (2004)
Other Product Names
Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3
Tested Applications
WB
Physical Properties
Liquid

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