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PTP1B Antibody

CAT: 0223-63-458Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-458Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
NCBI Gene ID
5770
Swiss Prot
P18031
Accession Number
P18031
Host
Rabbit
Reactivity
Human
Immunogen
This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPN1
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 1
NCBI Organism
Homo sapiens
Background Reference 01
Xu, J., et al., Biochem. Biophys. Res. Commun. 329 (2) :538-543 (2005) .
Background Reference 02
Palmer, N.D., et al., Diabetes 53 (11) :3013-3019 (2004) .
Background Reference 03
Bento, J.L., et al., Diabetes 53 (11) :3007-3012 (2004) .
Background Reference 04
Wiesmann, C., et al., Nat Struct Mol Biol 11 (8) :730-737 (2004) .
Other Product Names
Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTPN1, PTP1B
Tested Applications
WB
Protein ID
131467
Physical Properties
Liquid

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