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PCPTP1 Antibody

CAT: 0223-63-457Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-457Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PCPTP1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene for this protein predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of the gene for this protein was reported to be regulated by the nerve growth factor, which suggested a function in neuronal growth and differentiation.
NCBI Gene ID
5801
Swiss Prot
Q15256
Accession Number
Q15256
Host
Rabbit
Reactivity
Human
Immunogen
This PCPTP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-265 amino acids from the N-terminal region of human PCPTP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
74 kDa
Fragment
Rabbit Ig
Symbol
PTPRR
NCBI Official Name
Receptor-type tyrosine-protein phosphatase R
NCBI Organism
Homo sapiens
Background Reference 01
Blanco-Aparicio, C., et al., J. Cell Biol. 147 (6) :1129-1136 (1999) .
Background Reference 02
Ogata, M., et al., J. Biol. Chem. 270 (5) :2337-2343 (1995) .
Background Reference 03
Shiozuka, K., et al., Gene 162 (2) :279-284 (1995) .
Background Reference 04
Sharma, E., et al., J. Biol. Chem. 270 (1) :49-53 (1995) .
Other Product Names
Receptor-type tyrosine-protein phosphatase R, R-PTP-R, Ch-1PTPase, NC-PTPCOM1, Protein-tyrosine phosphatase PCPTP1, PTPRR, ECPTP, PTPRQ
Tested Applications
WB, IHC-P
Protein ID
134039192
Physical Properties
Liquid

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