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AK1 Antibody

CAT: 0223-63-437Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-437Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3) . AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
NCBI Gene ID
203
Swiss Prot
P00568
Accession Number
P00568
Host
Rabbit
Reactivity
Human
Immunogen
This AK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human AK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
AK1
NCBI Official Name
Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}
NCBI Organism
Homo sapiens
Background Reference 01
Corrons, J.L., et al., Blood 102 (1) :353-356 (2003) .
Background Reference 02
Toren, A., et al., Br. J. Haematol. 87 (2) :376-380 (1994) .
Background Reference 03
Zuffardi, O., et al., Hum. Genet. 82 (1) :17-19 (1989) .
Background Reference 04
Matsuura, S., et al., J. Biol. Chem. 264 (17) :10148-10155 (1989) .
Other Product Names
Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}, AK 1 {ECO:0000255|HAMAP-Rule:MF_03171}, 2743 {ECO:0000255|HAMAP-Rule:MF_03171}, 2746 {ECO:0000255|HAMAP-Rule:MF_03171}, ATP-AMP transphosphorylase 1 {ECO:0000255|HAMAP-Rule:MF_03171}, ATP:AMP phosphotransferase {ECO:0000255|HAMAP-Rule:MF_03171}, Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule:MF_03171}, Myokinase {ECO:0000255|HAMAP-Rule:MF_03171}, AK1 {ECO:0000255|HAMAP-Rule:MF_03171}
Tested Applications
WB
Protein ID
20178288
Physical Properties
Liquid

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