HK2 Antibody

• Background :

  In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Although found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.

• NCBI Gene ID :

  3099

• Swiss Prot :

  P52789

• Accession Number :

  P52789

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This HK2 (Hexokinase II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-431 amino acids from the Central region of human HK2 (Hexokinase II) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  102 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  HK2

• NCBI Official Name :

  Hexokinase-2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lehto, M., et al., Diabetologia 38 (12) :1466-1474 (1995) .

• Background Reference 02 :

  Vidal-Puig, A., et al., Diabetes 44 (3) :340-346 (1995) .

• Background Reference 03 :

  Laakso, M., et al., Diabetes 44 (3) :330-334 (1995) .

• Background Reference 04 :

  Echwald, S.M., et al., Diabetes 44 (3) :347-353 (1995) .

• Other Product Names :

  Hexokinase-2, Hexokinase type II, HK II, Muscle form hexokinase, HK2

• Tested Applications :

  WB, IHC-P

• Protein ID :

  56405344

• Physical Properties :

  Liquid