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PLK3 Antibody

CAT: 0223-63-364Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-364Size:400 µL
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Background
CNK, a member of the CDC5/Polo subfamily of Ser/Thr protein kinases, is involved in regulating M phase functions during the cell cycle. It may also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. This membrane-associated protein binds to the calcium/integrin-binding protein (CIB) . This interaction probably occurs via the POLO-box domain. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. This protein exhibits a short half-live. In cells of hematopoietic origin, CNK is strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Cytokine and cellular adhesion trigger CNK induction. CNK is thought to be phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis The protein contains 2 POLO box domains.
NCBI Gene ID
1263
Swiss Prot
Q9H4B4
Accession Number
Q9H4B4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 615-646 amino acids from the C-terminal region of human PLK3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
72 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PLK3
NCBI Official Name
Serine/threonine-protein kinase PLK3
NCBI Organism
Homo sapiens
Background Reference 01
Holtrich, U., et al., Oncogene 19 (42) :4832-4839 (2000) .
Background Reference 02
Ouyang, B., et al., Oncogene 18 (44) :6029-6036 (1999) .
Background Reference 03
Ouyang, B., et al., J. Biol. Chem. 272 (45) :28646-28651 (1997) .
Background Reference 04
Li, B., et al., J. Biol. Chem. 271 (32) :19402-19408 (1996) .
Other Product Names
Serine/threonine-protein kinase PLK3, Cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Polo-like kinase 3, PLK-3, Proliferation-related kinase, PLK3, CNK, FNK, PRK
Tested Applications
WB
Protein ID
51338822
Physical Properties
Liquid

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