PLK1 Antibody

CAT: 0223-63-298Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-298Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
NCBI Gene ID
5347
Swiss Prot
P53350
Accession Number
P53350
Host
Rabbit
Reactivity
Human
Immunogen
This PLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-603 amino acids from the C-terminal region of human PLK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
PLK1
NCBI Official Name
Serine/threonine-protein kinase PLK1
NCBI Organism
Homo sapiens
Background Reference 01
Ree, A.H., et al., Oncogene 22 (55) :8952-8955 (2003) .
Background Reference 02
Cheng, K.Y., et al., EMBO J. 22 (21) :5757-5768 (2003) .
Background Reference 03
Elia, A.E., et al., Cell 115 (1) :83-95 (2003) .
Background Reference 04
Lin, H.R., et al., J. Biol. Chem. 278 (38) :35979-35987 (2003) .
Other Product Names
Serine/threonine-protein kinase PLK1, Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13, PLK1, PLK
Tested Applications
WB, IHC-P
Protein ID
1709658
Physical Properties
Liquid

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